Doxorubicin hydrochloride pharmaceutical ingredien
ID:568481 View:1646次 | Collection |
Date Listed: | 2018-06-28 11:52:34 | Country: | China»Guangdong»Zhuhai |
Poster: | Jack | Company: | Zhuhai Wumei Technology |
Location: | No.5002 South Nanwan Road,Xiangzhou District | Website: | Zhuhai Wumei Technology |
Email: | jack@wumeitech.com | Mobile: | +86 17707567455 |
Fax: | 0756-8811095 | MSN: |
Doxorubicin hydrochloride Synonyms: ADRIACIN;ADRIBLASTINA;ADRIBLASTINA HYDROCHLORIDE;ADRIAMYCIN HCL;ADRIAMYCIN HYDROCHLORIDE;(8s-cis)-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride;14-HYDROXYDAUNOMYCIN HCL;14-HYDROXYDAUNOMYCIN HYDROCHLORIDE CAS: *-40-9 MF: C27H30ClNO11 MW: 579.98 EINECS: 246-818-3 Product Categories: APIs;Active Pharmaceutical Ingredients;API;Intermediates & Fine Chemicals;Pharmaceuticals;Antitumour;Adriamycin;inhibitor;Anti-cancer&immunity;Inhibitors. Chemical Properties Orange-Red Crystalline Solid.Used as an antineoplastic Uses Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.Antibacterial;DNA intercalant. Uses Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently. Uses: Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.
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