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Ferulic acid in the applicatio

ID:12422 View:1302
Date Listed: 2011-12-08 16:12:55 Country: China»Hubei»wuhan
Poster: Olina Li Company: hubei yuancheng pharmaceutical co.,ltd
Location: zhongshan road Website: hubei yuancheng pharmaceutical co.,ltd
Email: ycgsales29@gmail.com Mobile:
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Ferulic acid in the application of anti-platelet aggregation Under normal circumstances, we are all human blood platelets to form scattered in the blood. Platelet aggregation, is actually part of a process of coagulation, platelet adhesion with only one of many states. Essential thrombocythemia is a myeloproliferative disease characterized by bleeding tendency and thrombosis, peripheral blood platelet continued to increase significantly, function is not normal, excessive proliferation of bone marrow megakaryocytes. Because the disease often repeated bleeding, it is also called hemorrhagic thrombocythemia, common 40 years of age. National statistics, 30% person had arterial or venous thrombosis. Limb blood clots, may show numbness, pain, and even gangrene, but also the performance of erythromelalgia disease. Spleen and mesenteric vein thrombosis can cause abdominal pain, vomiting.Lung, brain, kidney embolism caused by the corresponding clinical symptoms, splenomegaly 80%, usually mild to moderate. A small number of patients have hepatomegaly. According to the degree of thrombocytosis, duration varies. Slow progress in most cases, the median survival time usually within 10 - 15 years or more. Few patients to bone marrow fibrosis, polycythemia vera or chronic myeloid leukemia. Major organ thrombosis and bleeding often based disease cause of death. At present, the choice of anticoagulants, aspirin (ASP) more effective, inexpensive, and more is recommended as the preferred anticoagulant. However, ASP may also occur in patients with resistance and other adverse reactions. In order to find new anti-platelet aggregation drugs, medical experts TMP, β-alanine, ferulic acid as starting materials, synthesis of six TMP aromatic acid ether β-alanine derivatives. Preliminary pharmacological results showed that six target compounds platelet inhibition rates were 6.4%, 27.4%, 7.7%, 14.8%, 37.0%, 10.9%.Further study found that one of the many can reduce 23% of thrombotic even....

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