Indole-3-carbinol,Food/Pharmac

Product?name:??Indole-3-carbinol(I3C)?Synonym:??3-Hydroxymethylindole,?3-Indolemethanol;?Indole-3-methanol?Appearance:???White?to?slightly?yellow?crystal?SPECIFICATION:???Min.?99%CAS?NO.:??700-06-1INECS:???211-836-2Molecular?formula:??C9H9NOMolecular?weight:???147.18Melting?point:???????96-99??CBoiling?point:???????360.6oC?at?760?mmHg?Analysis ItemSpecificationResultAssayAppearanceWhite to slightly yellow crystalCompliesTaste and OdorCharacteristicCharacteristicSolubilityEthanolCompliesMelting Range96-99?C97.0-98.7?CMoistureNMT 8.0%0.46%Heavy MetalsNMT 10ppmCompliesActive IngredientsNLT Indole-3-carbinol 99.0% HPLC99.20%Used as? Nutraceuticals, or Pharmaceutical intermediate for medicines.Indole-3-carbinol and its main metabolite diindoylmethane modulates several nuclear transcription factors resulting in a variety of biological and biochemical effects. Indole-3-carbinol works as a strong antioxidant, thereby protecting the DNA and other cell structures. - Chemopreventive: Indole-3-carbinol has chemopreventive activity and stimulates the production of detoxifying enzymes. The phytochemical protects against carcinogenic effect of pesticides and other toxins. - Anticancer:The anticancer effects of indole-3-carbinol and its metabolite diindoylmethane are the result of specific activities: inducing enzymes that metabolize carcinogens, enhancing DNA repair, inducing G1 cell cycle arrest and apoptosis. Indole-3-carbinol blocks estrogen receptor sites on the membranes of breast and other cells, thereby reducing the risk of cervical and breast cancer. Indole-3-carbinol increases the ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone and inhibits the 4-hydroxylation of estradiol. This is a favourable action of indole-3-carbinol because 16 alpha-hydroxyestrone and 4-hydroxyestrone have carcinogenic action. The estrogen metabolite 2-hydroxyestrone has protective against several types of cancer. Studies with animals have demonstrated that indole-3-carbinol reduced the carcino....

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