17 Alpha -Estradiol Sex Hormon

17 Alpha -Estradiol Sex Hormone Steroids 57-91-0 Basic info. Estradiol Other name: 17α -estradiol CAS: 57-91-0 EINECS: 200-023-8 Molecular formula: C18H24O2 Molecular weight: 272.38 Melting point: 176-180 ° C Assay: 98% Estradiol Description: Estradiol, or more precisely, 17β estradiol, is a human sex hormone and steroid, and the primary female sex hormone. It is named for and is important in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is essential for the development and maintenance of female reproductive tissues but it also has important effects in many other tissues including bone. While estrogen levels in men are lower compared to women, estrogens have essential functions in men as well. Estradiol is found in most vertebrates as well as many crustaceans, insects, fish, and other animal species. Estradiol or oestradiol (American or British English usages), derives from estra Gk. οστρο (oistros, literally meaning "verve or inspiration [4] and diol, a chemical name and suffix indicating that this form of steroid and sex hormone is a type of alcohol bearing two hydroxyl groups. Estradiol is produced especially within the follicles of female ovaries, but also in other endocrine (i.e., hormone producing) and non endocrine tissues (e.g., including fat, liver, adrenal, breast, and neural tissues). Estradiol is biosynthesized from progesterone (arrived at in two steps from cholesterol, via intermediate pregnenolone).[citation needed] One principle pathway then converts progesterone to its 17-hydroxy-derivative, and then to androstenedione via sequential cytochrome P450-catalyzed oxidations.[citation needed] Action of aromatase on this dione generates estrone, and action of a dehydrogenase on this gives the title compound, 17β-estradiol.[citation needed] Application: Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17....

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