Analgesic Antipyretic / Phenac

Analgesic Antipyretic / Phenacetins Pharmaceutical Intermediates Basic info. English name: Phenacetin-Acetate EINECS number: 200-533-0 Molecular formula: C10H13NO2 Molecular Weight: 179.2157 Molecular structure: Density: 1.099g/cm3 Melting point: 133-138 oC Boiling point: 355.1 ° C at 760 mmHg Flash Point: 168.5 ° C Water-soluble: 0.076 g / 100 mL Vapor Pressure: 3.21E-05mmHg at 25 ° C Assay: 100.58% Appearance: White crystalline powder Descriptions: Using for : reliving wound pains Section 1st. It is also called acetophenetidin. Having glossy leaflets or scales-like crystals that have no odor or taste. Melting point 134 ~ 137. Stable in air, soluble in water, slightly soluble in boiling water, slightly soluble in ether, soluble in ethanol, chloroform. It is formed through the etherification,reduction and Acetylation reaction of pchloronitrobenzene. As chloroacetanilide antipyretic and analgesic agent. Suitable for fever,headache, neuralgia and other drugs as a compound agent. Section 2nd. Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting as aspirin, low toxicity. Research shows that: This product and its metabolites acetaminophen have the antipyretic effect. Because the enzyme inhibitor make phenacetin-Acetate not be converted into paracetamol, still showed obvious antipyretic effect,thus the antipyretic effect after the product line not converrt to paracetamol.The mild phenacetin-Acetate analgesic effect usually lasts 3 to 4 hours; and synergistic effect, of alicylic acid coadministrationmake the analgesic effect enhancement. The main clinical is for small animal antipyretic analgesic. This product is also a component of the APC tablet. Setion 3rd. Phenacetin-Acetate is a pain-relieving and fever-reducing drug, widely used from its introduction in 1887 until banned in the US by the FDA in 1983. Its use has declined because of its adverse ef....

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