Tolnaftate

CAS 2398-96-1 Tolnaftate Product Name: Tolnaftate CAS: 2398-96-1 MF: C19H17NOS MW: 307.41 Assay: 99.5% Melting Point: 110.5-111.5℃ Loss on Drying: 0.03% Usage: Antifungal Agents Medicine Grade: Antifungal Agents Appearance: White Powder Solubility: <0.1 g/100 mL at 22 HazardClass: IRRITANT Residue On Lgnition: 0.01% Heavy Metals: ≤ 0.002% Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, and liquid aerosol. Tolnaftate is used to treat fungal conditions such as jock itch, athlete's foot and ringworm. Mechanism Although the exact mechanism of action is not entirely known, it is believed to inhibit squalene epoxidase,an important enzyme in the biosynthetic pathway of ergosterol (a key component of the fungal membrane) in a similar way to allylamines. Uses Tolnaftate has been found to be generally slightly less effective than azoles when used to treat tinea pedis (athlete's foot). It is, however, useful when dealing with ringworm, especially when passed from pets to humans.

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