Megestrol acetate

Refined Powder Female Steroidal Progestin Hormone CAS 595-33-5 Megestrol Acetate  Basic information:   Product Name: Megestrol acetate Synonyms: 17-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione; 6-dehydro-6-methyl-17-alpha-acetoxyprogesterone; 6-Dehydro-6-methyl-17alpha-acetoxyprogesterone CAS: 595-33-5 MF: C24H32O4 MW: 384.51 EINECS: 209-864-5 Product Categories: Active Pharmaceutical Ingredients;Antitumors for  Research and Experimental Use;Biochemistry;Hydroxyketosteroids;Steroids;   Product Description : Megestrol acetate (INN, USAN, BAN, JAN) (abbreviated as MGA or MA, and sold mainly under the brand names Megace and Megace ES), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects. Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound. Megestrol acetate has powerful antiandrogenic and antiestrogenic effects in humans at sufficient doses, capable of decreasing circulating androgen and estrogen concentrations to castrate levels in both sexes and significantly lowering the expression of the androgen receptor (AR) and the estrogen receptor (ER) in the body. As an example, one study in men with benign prostatic hyperplasia who were treated with 120-160 mg of megestrol acetate per day for 3 to 11 days found average decreases in AR quantity of 73% and 86% in the cytoplasm and nucleus of prostatic cells, respectively.These actions are likely the result of a strong activation of the PR, which suppresses the secretion of the gonadotropins-peptide hormones responsible for signaling the body to produce not only progesterone but also the androgens and the estrogens-from the pituitary gland as a form of negative feedback inhibition, an

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